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Abstract #0603

First-in-human: tackling the hypoxic challenge in breast cancer with advanced MRI

Katja Pinker-Domenig1, Barbara Bennani-Baiti 1, Thomas Helbich1, Max Zimmermann2, Pascal Baltzer1, Paola Clauser1, Pangiotis Kapteas1, Zsuzsanna Bago-Horvath3, Peter Dubsky4, Rupert Bartsch5, and Andreas Stadlbauer2

1Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Neurosurgery, University of Erlangen-N├╝rnberg, Erlangen, Germany, 3Department of Pathology, Medical University of Vienna, Vienna, Austria, 4Department of Surgery, Medical University of Vienna, Vienna, Austria, 5Department of Internal Medicine, Medical University of Vienna, Vienna, Austria

To develop a novel MRI approach for the non-invasive assessment of hypoxia and neovascularization in benign and malignant breast tumors and to provide insights into the intratumoral heterogeneity of breast cancer. 76 patients with a BI-RADS 4/5 lesion underwent 3T MRI of the breast with Vascular Architecture Mapping (and quantitative Blood Oxygenation Level Dependent (qBOLD) imaging. Our approach demonstrated that breast cancer consumes more oxygen and is more hypoxic and neovascularized than benign tumors. This non-invasive approach can be easily integrated in a diagnostic MRI protocol and has the potential to improve tumor characterization and facilitate tailored breast cancer treatment.

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