Osteoarthritis is a major societal burden and is associated with pain and disability. To cope with the “osteoarthritis epidemic” and its high associated costs, there is a need for new conservative treatments. This study investigates the potential of gait retraining with altered foot progression angle as one inexpensive conservative treatment for medial knee osteoarthritis. Our results show that this treatment may be effective in reducing pain and improving the MRI outcomes in osteoarthritis patients. This suggests the potential of personalized gait retraining with altered foot progression angle as an inexpensive and effective conservative method for the management of osteoarthritis patients.