Brain metabolite T1 and T2 have diagnostic value and per-subject knowledge of both metabolite and water reference T1, T2 is necessary for accurate metabolite absolute quantification. Here we optimize the excitation schedules of our recently-proposed magnetic resonance spectroscopic fingerprinting (MRSF) sequence to accurately estimate metabolite T1 and T2. We computationally evaluate the optimized schedules using Monte-Carlo simulations, as well as phantom and in-vivo experiments.
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