Localized proton magnetic resonance spectroscopy (MRS) provides a non-invasive tool for metabolic studies on biological systems by revealing valuable biochemical information, complementary to anatomical information delivered by MRI. However, due to limited proton chemical shift range and extensive J coupling splittings, spectral congestion is generally encountered in the resulting 1D spectra acquired by conventional proton MRS techniques, such as PRESS (Point resolved spectroscopy) and STEAM (STimulated Echo Acquisition Mode). In this abstract, we present a previously-unreported proton MAS approach to obtain localized 1D pure shift spectra with spectral simplification, potentially useful for studies on biological samples.
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