We have investigated the mechanical development of the mouse brain from 4 weeks to 20 weeks by multifrequency MR elastography and performed proteomics analysis with mass spectrometry. Highly resolved elastographic atlases of brain maturation were generated and regional analysis was performed to identify areas with age-dependent changes in viscoelasticity. In hippocampus, molecular signatures associated with macroscopically observed mechanical profile were identified, suggesting a transition from a soft-fluid to a more elastic-solid state during maturation. Combining MRE and proteomic analysis, we provide structural and functional information related to brain maturation from the molecular level up to whole-organ mechanical scale.
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