The human connectome project has demonstrated the enormous potential of functional and structural connectomics in understanding the brain. Extension of connectomics to mouse models has analogous potential, particularly where genetic variation can be controlled and manipulated. But the methods developed for human are not immediately extensible to the mouse models. We have developed a long term strategy, methods and infrastructure to make mouse connectomics routine with validation against tracer techniques. This project represents our first effort to deploy the methods in a study of heritability in a controlled collection of 4 genetically different strains.