Abstract #1227

Multi-Parametric MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis (NASH)

Iris Y. Zhou¹, Veronica Clavijo Jordan¹, Nicholas Rotile¹, Smitha Krishnan², Hema Krishnan¹, Gunisha Arora², Hannah Slattery¹, Noah Warner¹, Christian T. Farrar¹, Bryan C. Fuchs², and Peter Caravan¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Noninvasive MR quantification of matrix using a collagen-binding molecular MR probe and tissue stiffness by MR elastography were used to assess liver fibrosis and the anti-fibrotic effects of elafibranor or diet change in a rat model of nonalcoholic steatohepatitis (NASH). Reduction of fibrosis after diet change or elafibranor treatment were detected by EP-3533 collagen imaging and stiffness measurements and correlated with morphometric assessment of fibrosis from histology and with hydroxyproline content as a biochemical surrogate for total liver collagen. Multi-parametric MRI can be used to characterize disease progression and serve as sensitive tool for evaluating treatment response.

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