Abstract #1708

A Two-Center Analysis of Hyperpolarized 129Xe Lung MRI in Stable Pediatric Cystic Fibrosis: Comparison of Image Analysis Approaches

Marcus J. Couch^1,2, Robert Thomen³, Felix Ratjen^1,4, Jason Woods⁵, and Giles Santyr^1,2

¹Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³School of Medicine, University of Missouri, Columbia, MO, United States, ⁴Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

The ventilation defect percent (VDP), measured from hyperpolarized ¹²⁹Xe MRI, is sensitive to functional changes in early cystic fibrosis (CF) lung disease; however, there is no consensus on which VDP calculation method is most appropriate for future multi-center clinical trials in CF. This study compared VDP analysis methods in hyperpolarized ¹²⁹Xe datasets acquired in stable pediatric CF subjects at two institutions. In a combined dataset, a comparison of k-means, mean-anchored linear binning, and 99th percentile-anchored linear binning demonstrated that all three methods provide a good characterization of the disease, but mean-anchored linear binning provided the strongest correlation to pulmonary function tests.

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