Abstract #2004

Imaging myocardial reperfusion injury using cardiac quantitative susceptibility mapping

Brianna F. Moon¹, Srikant Kamesh Iyer, PhD², Eileen Hwuang¹, Michael P. Solomon¹, Anya T. Hall¹, Rishabh Kumar³, Elizabeth M. Higbee-Dempsey³, Andrew Tsourkas, PhD¹, Yoshiaki Saito, MD⁴, Akito Imai, MD⁴, Keitaro Okamoto, MD⁴, Avanti Gulhane, MD², Harold Litt, MD-PhD², William Matthai, MD⁵, James J. Pilla, PhD², Joseph H. Gorman III, MD⁴, Robert C. Gorman, MD⁴, Samuel J. Keeney^4,6, Victor A. Ferrari, MD⁵, Giovanni Ferrari, PhD⁷, and Walter R. Witschey, PhD^1,2,3

¹Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, United States, ⁴Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁵Medicine, Perelman School of Medicine, Penn Presbyterian Medical Center, Philadelphia, PA, United States, ⁶Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ⁷Surgery, Columbia University, New York City, NY, United States

Hemorrhage is a frequent complication of reperfusion therapy for acute myocardial infarction (MI). This study investigated reperfusion injury with respect to the duration of myocardial ischemia by analyzing magnetic susceptibility, an endogenous imaging biomarker of tissue iron, in a large animal model. We demonstrate with cardiac quantitative susceptibility mapping (QSM), there is a significant shift in infarct tissue magnetic susceptibility with longer time-to-reperfusion and non-reperfused infarcts compared to remote myocardium which correlates with iron content and infarct pathophysiology.

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