Abstract #2023

Combined SAturation recovery and Variable flip Angle (SAVA) for free-breathing high-resolution three-dimensional cardiovascular magnetic resonance T1 mapping at 3T

Rui Guo¹, zhensen chen^1,2, Dongyue Si¹, Daniel A. Herzka^3,4, jianwen luo¹, and Hanyan Ding¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Vascular Imaging Laboratory, Department of Radiology, Vascular Imaging Laboratory, Seattle, WA, United States, ³National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States

Cardiac Magnetic Resonance T₁ mapping enables quantitative characterization of myocardium, which appeals huge attention from clinic. In this work, we proposed a free-breathing high-resolution three-dimensional (3D) T₁ mapping sequence. By using variable flip Angle technique for readouts and saturation-recovery preparation for T₁ weightings, the proposed sequence is highly efficient in acquisition of all volumes, including the one at the equilibrium of the longitudinal magnetization. Whole-heart pre- and post-contrast homogeneous T₁ maps at an imaging resolution 1.25×1.25×8 mm³ were successfully obtained within 10 minutes in healthy volunteers. After rigid registration, 3D Extracellular Volume maps were eventually achieved.

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