We have monitored
myocardial perfusion (MBF) dynamically under pharmacologically-induced stress
in mice using a time-optimized cine-ASL MRI approach with about 2.5min temporal
resolution. One main advantage of the repeatable cine-ASL in this context is to
monitor MBF during successive stress episodes in the same animal allowing for
internal control. In this study we clearly demonstrated that single bolus nicotine
administration (1mg·kg-1) significantly reduced perfusion by 35%
under adenosine stress (tail vein continuous infusion, 90µg·kg-1·min-1) in healthy mice.