Abstract #2357

Quantitative ADC measurement of breast cancer with ssEPI and reduced FOV diffusion weighted imaging techniques

Benjamin Charles Musall¹, Beatriz E Adrada², Abeer H Abdelhafez², Hagar S Mahmoud², Ken-Pin Hwang¹, Jong Bum Son¹, Lumarie Santiago², Gary J Whitman², Huong Le-Petross², Tanya W Moseley², Rosalind P Candelaria², Thorunn Helgason³, Elizabeth E Ravenburg³, Jennifer K Litton³, Stacy L Moulder³, Wei T Yang², Jingfei Ma¹, Mark D Pagel⁴, and Gaiane M Rauch²

¹Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ²Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX, United States, ³Breast Medical Oncology, MD Anderson Cancer Center, Houston, TX, United States, ⁴Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States

The goal of this study was to assess differences in quantitative ADC of breast cancer between ssEPI and rFOV DWI techniques. The two techniques were used to acquire breast DWI images in 27 patients at three different time points during their neoadjuvant chemotherapy. Tumor ADC from the two techniques at baseline and mid-treatment scans show strong correlation and minimal bias. However, tumor ADC from the two techniques at pre-surgery correlated more moderately and showed a slight bias. The relative and absolute changes in ADC at mid-treatment or pre-surgery from baseline showed only moderately-strong non-parametric correlation between the two techniques.

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