Parkinson’s disease (PD) is a common progressive neurodegenerative disorder characterized by resting tremor, bradykinesia, restricted mobility, and postural instability. PD has a progressive course and is associated with increased mortality, with physical disability and non-motor symptoms exerting a significant negative impact on quality of life. Robust early prediction of clinical outcomes in Parkinson’s disease would be paramount for implementing appropriate management interventions. The predictive power varied according to the clinical measures used and was highest in the prediction of UPDRS. This finding was further confirmed by using bootstrap approach and leave-one-out cross-validation analysis.