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Abstract #2582

Analysis of changes in brain structure in patients with Parkinson's disease and their correlation with the Hoehn-Yahr stage using the MPRAGE sequence

Chunyan Zhang1, Ruichen Zhao1, Jinxia Zhu2, Tobias Kober3, Chen Chen1, Hong Lu4, Hongcan Zhu4, Bing Xue4, Hong Liang4, and Jingliang Cheng1

1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare, Ltd., Beijing, China, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

In this study, the volume changes of brain structure in Parkinson's disease (PD) patients were analyzed. We found extensive structural brain changes in PD patients, and most of these changes were correlated with the Hoehn-Yahr stage. The results showed that volume changes in some brain regions may be a potential imaging marker for early diagnosis of PD, and the MPRAGE sequence may be a suitable and quick method to provide a reference for clinicians to diagnose PD.

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