In this study, we aim to evaluate the relationships between fiber connectivity starting from specific nucleus regions to the whole brain and the Unified Parkinson’s Disease Rating Scale (UPDRS)-III scores in patients with Parkinson's disease. The results showed that the structural connectivity to the whole brain starting from bilateral internal global pallidus and caudate nucleus has significant negative correlations with the UPDRS-III scores. In the contrary, no significant correlations was found for the network starting from the putamen and external global pallidus. The strong negative correlation implies that these specific nuclei may play significant roles in the severity of Parkinson's disease. This finding is of great importance for further clinical research.