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Abstract #2592

Temporal Atrophy Predicts the Deterioration of Cognition in Multiple Domains: a Longitudinal Clinical Study in Parkinson’s Disease

Cheng Zhou1, Xiaojun Guan1, Tao Guo1, and Minming Zhang1

1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China

To specify the critical structural alterations of cognitive deterioration in Parkinson’s disease (PD) and explored the underlying mechanism of structural changes. We combined cross-sectional and longitudinal VBM analyses to explore the structural topologies between PD patient who convert to mild cognitive impairment (PD converter). The relationships between dopamine transporter (DAT), CSF proteins and structural alterations were assessed. PD converters showed progressive temporal atrophy associated with multiple cognitive domains. DAT results were significantly associated with temporal atrophy. In conclusion, temporal lobe is a crucial node in modulating cognitive status in multi-domains. Dopamine deficiency may contribute to cognition-related temporal atrophy.

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