Abstract #2593

Functional Brain Connectome and Mild Cognitive Impairment in Early Stage Parkinson Disease

Xueling Suo¹, Du Lei¹, Nannan Li², Wenbin Li¹, Lan Cheng², Meiyun Wang³, Rong Peng², and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Neurology, West China Hospital of Sichuan University, Chengdu, China, ³Department of Radiology, Henan Provincial People’s Hospital & the People’s Hospital of Zhengzhou University, Zhengzhou, China

To use graph theory approaches and resting-state functional magnetic resonance imaging (MRI) to explore the brain functional network in patients with early stage Parkinson's disease (PD) and mild cognitive impairment (MCI). The whole-brain functional network was constructed by thresholding the Pearson correlation matrices of 90 brain regions. The results showed a less small-worldization characterized by decreased global integration and decreased local segregation in PD patients relative to healthy controls (HC). On the basis of these between-group difference in global and nodal properties, PD patients with MCI showed the lowest properties values, followed by PD patients with normal cognition and HC.

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