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Abstract #2648

High resolution diffusion magnetic resonance imaging based atlas of the C57BL/6J adult mouse brain: a tool for examining mouse brain structures

Tanzil Mahmud Arefin1, Choong Heon Lee1, Orlando Aristiz√°bal1,2, Youssef Zaim Wadghiri3,4, Daniel Turnbull1,2, and Jiangyang Zhang1

1Department of Radiology, New York University School of Medicine, New York, NY, United States, 2Skirball Institute of Biomolecular Medicine, New York, NY, United States, 3Bernard & Irene Schwartz Center for Biomedical Imaging, New York, NY, United States, 4Preclinical Imaging Center, New york, NY, United States

Mouse models have been widely used in the neuroscience research to evaluate brain development, micro-structural and functional phenotypes in response to gene mutations and neurological diseases which require a baseline for comparison, such as an atlas. Where existing atlases vary in contrast mechanisms, number of structures and resolution, very few reports detailed neuroanatomical parcellations based on diffusion magnetic resonance imaging. This study was therefore aimed to develop high resolution diffusion MR-based mouse brain atlas database with thorough labels for cortical and subcortical structures compatible with the Allen Mouse Brain Atlas (AMBA) which will be freely available to the research community.

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