Abstract #2745

Use of NODDI for Microstructural Characterization of Posterior Limb of the Internal Capsule in Subacute and Chronic Stroke Patients

Alfonso Mastropietro¹, Maria Luisa Malosio^2,3, Lucia Fontana⁴, Laura Straffi⁵, Simona Marcheselli⁵, Bruno Bernardini⁶, Sara Ghirmai⁶, Nunzio Paolo Nuzzi⁴, Giovanna Rizzo¹, and Marco Grimaldi⁴

¹Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Segrate, Italy, ²Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Milano, Italy, ³Laboratory of Brain Pathology and Pharmacology and Neuro Center, Humanitas Clinical and Research Center, Rozzano, Italy, ⁴Neuroradiology Unit and Neuro Center, Humanitas Clinical and Research Center, Rozzano, Italy, ⁵Stroke Unit and Neuro Center, Humanitas Clinical and Research Center, Rozzano, Italy, ⁶Neurorehabilitation Unit and Neuro Center, Humanitas Clinical and Research Center, Rozzano, Italy

This preliminary work shows that NODDI, supplementing the classical DTI approach, could provide a new insight into the subtle micro-architectural modifications occurring in the posterior limb of the internal capsule of 10 stroke patients in subacute and chronic phase.

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