Stroke is a treatable disease and neuroimaging can identify salvageable tissue, directly impacting treatment decisions. Women experience stroke differently than men with higher severity, worse outcomes, and varying therapeutic response. We examined the contribution of sex and age to stroke outcome with emphasis on therapeutic targets on MRI. MR images were evaluated for predictive imaging factors. A 90-day mRS was obtained to assess functional independence. Women present more often with treatable ischemic stroke than men as defined by MR imaging factors. Sex modulates the age-dependent stroke outcome but upon stratification for treatment, difference in outcome favoring men was not observed.