Evaluating Countermeasures Against Chemical Warfare Nerve Agents using Diffusion Tensor Imaging
Kevin Lee1, Matthew Bouchard1, Sara Bohnert2, Steven D Klaassen3, Roland M van den Berg3, Marloes J.A. Joosen3, and Jeff F. Dunn1
1Radiology, University of Calgary, Calgary, AB, Canada, 2Defence Research and Development Canada-Suffield Research Centre, Ralston, AB, Canada, 3CBRN Protection, TNO, Rijswijk, Netherlands
Seizures induced by chemical warfare nerve agents cause debilitating neurological damage. It is widely accepted that the main contributor to this neuropathology is excitotoxic damage. Current countermeasures to the damage are effective in preventing mortality, but do not always prevent nerve agent-induced seizures and related neuropathology. We have applied diffusion tensor imaging to study the microstructural changes in the brain to evaluate the efficacy of countermeasures against chemical warfare nerve agents.
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