Multiple sclerosis (MS) is a CNS autoimmune disease of unknown etiology. Prior MS studies have characterized an inflammatory process involving the perivascular spaces (PVSs) of a central vein, but have reported conflicting results regarding which aspects of PVS anatomy correlate to clinical aspects of the disease. This preliminary study compared percentages of manually marked perivenular and non-perivenular PVSs in relapsing-remitting MS patients and healthy controls, and detected a higher rate of vein-coincident PVSs in the former group. We posit that perivenular PVSs have potential as a candidate imaging marker for MS diagnosis, disease activity, and treatment efficacy.
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