Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy. Neuroimaging and neuropathological studies indicates that the structural network affected in TLE extends to both temporal and extra-temporal structures. In this work, quantitative 3DMT maps were used in a Voxel Based Morphometry(VBM) framework to assess atrophy in left and right TLE compared to controls. Our findings revealed that 3DMT maps, thankfully to their excellent grey-white matter contrast, can be successfully employed for VBM in epilepsy identifying temporal and extra-temporal grey and white matter alterations in patients. This study is a proof-of-principle to adopt 3DMT for voxel based analysis in TLE.