This study aimed to preliminarily investigate the utility of MAP-MRI parameters in hippocampal sclerosis and compare them with traditional DTI parameters to explore the changes in hippocampal microstructure and understand its pathophysiological mechanisms. The swelling of the hippocampal nerve fiber axon presynaptic terminal can be reflected by MAP-MRI, which greatly assists in the clinical diagnosis of early hippocampal sclerosis. Compared with DTI parameters, DSI parameters showed higher diagnostic efficacy particularly for RTPP and QIV. This study extracted more objective and reproducible parameters of fixed hippocampal sclerosis. More samples are needed for future research.