The hippocampus is involved in a variety of cognitive and functional tasks. Research groups rely on volumetric segmentations to assess: the integrity of the HC and its subfields as well as their involvement in cognitive tasks. Unfortunately, due to its size and location, most studies use non-isotropic T2-weighted images to segment the HC. The aim of this project is to determine whether partial volume effects due to T2-weighted slice angulation and non-isotropic resolution have an impact in the segmentation process. The results indicate that both, angulation and non-isotropic acquisition have a significant impact in specific subfields.