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Abstract #3147

Evaluating brain oxygen metabolism and cognition in multiple sclerosis

Kathryn L West1, Dinesh K Sivakolundu1, Mark D Zuppichini1, Gayathri B Maruthy1, Darin T Okuda2, Hanzhang Lu3, and Bart Rypma1

1Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United States, 2Neurology, University of Texas Southwestern, Dallas, TX, United States, 3Radiology, Johns Hopkins University, Baltimore, MD, United States

We used phase contrast (PC) and T2-Relaxation-Under-Spin-Tagging (TRUST) to evaluate whole brain cerebral metabolic rate of oxygen (CMRO2) in MS patients and healthy controls. We compared CMRO2 with cognitive performance and diffusion kurtosis imaging. CMRO2 correlates negatively with cognitive function in MS patients, suggesting a marker of ongoing disease activity leading to cognitive decline.

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