Abstract #3148

Relevance of cortical and subcortical integrity in cognitive performance in Relapsing-Remitting Multiple Sclerosis patients.

Cristian Montalba^1,2,3, Mariana Zurita⁴, Tomás Labbé^1,5, Marcelo Andia^1,2,3, Miguel Guevara⁶, Jean-François Mangin⁷, Juan Pablo Cruz², Ethel Ciampi^8,9, Cristian Tejos^1,3,10, Claudia Cárcamo^8,11, Pamela Guevara⁶, and Sergio Uribe^1,2,3

¹Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, ⁴Institute of Cognitive Neuroscience., University College London, London, UK., London, United Kingdom, ⁵Interdisciplinary Center of Neurosciences, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Faculty of Engineering, University of Concepción, Concepción, Chile, ⁷Université Paris-Saclay, Paris, France, ⁸Neurology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁹Neurology Service, Hospital Dr. Sótero del Río, Santiago, Chile, ¹⁰Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ¹¹Interdisciplinary Center of Neurosciences, Pontificia Universidad Católica de Chile, Santiago, Chile

In this work, we evaluated if structural characteristics of cortical regions and the U-fibers connected to these regions allows predicting multiple sclerosis patients’ score in FAS, SDMT and PASAT tests. For this purpose, we represented structural characteristics as the proportion of the regions and fibers covered by lesion and the U-fiber’s mean fractional anisotropy. In our sample, FAS test score results significantly correlated with structural damage in U-fibers from Frontal and Temporal lobes. PASAT test score significantly correlated with structural damage in U-fibers in the bilateral Frontal and Parietal lobes. No significant correlations were found for the SDMT.

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