Abstract #3162

Spatial distribution of multiple sclerosis lesions along the brain and spinal motor tracts and correlation with functional deficits

Anne Kerbrat^1,2, Charley Gros¹, Atef Badji¹, Elise Bannier^3,4, Francesca Galassi⁴, Benoit Combès⁴, Pierre Labauge⁵, Xavier Ayrignac⁵, Clarisse Carra Dallière⁵, Frederic Pinna⁵, Benjamin De Leener⁶, Dominique Eden¹, Josefina Maranzano⁶, Ren Zhuoquiong⁷, Tobias Granberg⁸, Leszek Stawiarz⁸, Jan Hillert⁸, Russell Ouellette⁸, Jason Talbott⁹, Yasuhiko Tachibana¹⁰, Masaaki Hori¹¹, Kouhei Kamiya¹¹, Lydia Chougar¹², Jennifer Lefeuvre¹³, Daniel Reich¹³, Govind Nair ¹³, Paola Valsasina¹⁴, Maria Rocca¹⁴, Massimo Filippi¹⁴, Renxin Chu¹⁵, Rohit Bakshi¹⁵, Gilles Edan², and Julien Cohen-Adad^1,16

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Neurology, CHU de Rennes, Rennes, France, ³Radiology, CHU de Rennes, Rennes, France, ⁴Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, Visages U1128, Rennes, France, ⁵CHU Montpellier, Montpellier, France, ⁶McConnell Brain Imaging Center, Montreal neurological institute, Montreal, QC, Canada, ⁷Xuanwu Hospital, Beijing, China, ⁸Karolinska Institutet, Stockholm, Sweden, ⁹Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, United States, ¹⁰National Institute of Radiological Sciences, Chiba, Japan, ¹¹Juntendo University Hospital, Tokyo, Japan, ¹²Hopital Cochin, Paris, France, ¹³National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ¹⁴Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ¹⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ¹⁶Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada

We describe the spatial distribution of multiple sclerosis (MS) lesions in the corticospinal tracts (CST), from the cortex to the lower cervical cord, using an open-source automated pipeline. We confirm the high frequency of CST focal damage in MS patients from the first year of relapsing-remitting MS and identify areas of predilection for MS lesions along the CST in the cervical spinal cord. At baseline, no significant correlation was observed between brain or spinal cord CST lesion volume fraction and physical disability scores. However, the baseline spinal cord CST lesion volume fraction correlated with the EDSS at 2 years.

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