Experimental autoimmune encephalomyelitis (EAE) in the common marmoset (Callithrix jacchus) shares important pathological and radiological similarities with MS. However, cortical pathology in this model has not been investigated by MRI. The purpose of this study is to examine, for the first time, whether cortical lesions can be visualized by MRI in this model. Similar to MS patients, we report the MRI detection of MS-like cortical lesions in postmortem EAE marmoset. These findings further reinforce the proximity between this animal model and the human disease.