Abstract #3354

Nyquist Ghost Correction of High-Resolution SMS Breast DWI with Ghost/Object Minimization

Jessica A McKay^1,2, Steen Moeller^2,3, Sudhir Ramanna^2,3, An L Church³, Michael T Nelson³, Edward J Auerbach^2,3, Kamil Ugurbil^2,3, and Patrick J Bolan^2,3

¹Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³Radiology, University of Minnesota, Minneapolis, MN, United States

A recent novel approach to acquire high-resolution breast DWI uses a simultaneous multi-slice (SMS) SE-EPI sagittal acquisition. In EPI, Nyquist ghosts are typically corrected using a 3-line navigator, which often fails in SMS SE-EPI breast DWI due to low SNR, insufficient fat suppression, and larger B₀ inhomogeneity. In this work we compare a referenceless ghost correction method, called Ghost/Object minimization, with the standard 3-line navigator in high-resolution breast DWI. Ghost/Object provides more reliable 1st-order ghost correction in a dynamic and slice-specific way, which improves image quality and reduces bias in ADC values compared to the standard correction.

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