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Abstract #3428

High Spatial Resolution Multi-shell DTI in Children and Young Adults Prenatally Exposed to Alcohol

Pascal T├ętreault1, Sarah Treit1, Graham Little1, Emily Stolz1, and Christian Beaulieu1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

Diffusion tensor imaging (DTI) has identified white matter differences in individuals with prenatal alcohol exposure (PAE). The current study uses higher spatial resolution of 1.5 mm isotropic (3.4 mm3 voxels) and larger b-values of 2000 s/mm2 (in addition to typical 1000 s/mm2) to assess the brain in children to young adults with PAE. Using the ICBM DTI template regions-of-interest for white matter, the b2000 tensor metrics (but not b1000) showed group differences in the left medial lemniscus and left stria terminalis, the latter also showing correlations with age in the control group but not the PAE group.

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