This study investigates mapping of Surface-to-Volume (S/V) ratios from short diffusion time derived ADC maps to detect and characterize prostate cancer. ADC was mapped using a cos-OGSE DWI (fosc=50-200Hz) in one unfixed prostate (Gleason 4+4). Using a previously established model, S/V and free cytosol diffusivity (D0) maps were estimated by fitting the temporal behaviour of ADC. S/V and D0 were able to clearly and significantly separate the cancer and normal peripheral zone as indicated by a t-test and ROC curves. The geometrical nature of S/V may provide additional information to better characterize prostate cancer independent from diffusion related parameters.