Abstract #3546

Diffusion Time Dependence in Crossing Fiber Area in in vivo Human White Matter

Masaaki Hori¹, Tomoko Maekawa^1,2, Kouhei Kamiya², Yasuhiko Tachibana³, Koji Kamagata¹, Issei Fukunaga¹, Katsutoshi Murata⁴, Thorsten Feiweier⁵, Akifumi Hagiwara^1,2, Shohei Fujita^1,2, Ryusuke Irie^1,2, Christina Andica¹, Kanako Kunishima Kumamaru¹, Akihiko Wada¹, and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Radiology, National Institute of Radiological Sciences, Chiba, Japan, ⁴Siemens Japan K.K, Tokyo, Japan, ⁵Siemens Healthcare GmbH, Erlangen, Germany

We investigated the diffusion time dependency of diffusion metrics in the white matter crossing fiber areas with different diffusion times using OGSE, PGSE and STEAM-DTI in in vivo human white matter at 3T. Our results show that ADC and AD decreased with increasing diffusion time at Δless than 100ms; after that ADC increased with increasing diffusion time. RD decreased and FA increased with increasing diffusion time. Moreover, the changes of white matter fODF in the white matter crossing fiber area at different diffusion times are shown.

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