Multiparametric MRI has been investigated in breast and prostate cancer, and other tumors. We evaluated diffusion weighted imaging in a pilot cohort of 20 malignant and 11 benign breast cancer patients, and 7 healthy women. MR spectra were recorded using an accelerated version of five dimensional echo-planar correlated spectroscopic imaging (5D EP-COSI). Significant decline in ADC values of malignant breast cancer compared to benign and healthy women. There was a negative correlation of choline with ADC values in malignant cancer patients. Our findings suggest that choline and lipids can be reliable biomarkers in addition to widely used ADC.