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Abstract #3608

Diffusion Kurtosis Image in assessment of 3D Cell Culture

Jui-Heng Lin1, Huei-Chun Hsiao1, Shao-Chieh Lin1, Yi-Jui Liu2, Ruey-Hwang Chou3, Ke-Sin Yan3, Tan-Wei Liao3, Chao-Chun Lin4, Chia-Wei Lin4, and Wu-Chung Shen4

1Master's Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichung, Taiwan, 2Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 3Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, 4Department of Radiology, China Medical University Hospital, Taichung, Taiwan

A non-Gaussian kurtosis model has been shown to take into account tissue heterogeneity and two relative imaging biomarkers namely, the kurtosis coefficient and the corrected diffusion coefficient can be quantified. In this study, 3D cell culture with hydrogels ECM was used to investigate whether DKI may provide information on these microenvironmental parameters and the microenvironment-associated metastatic propensity of tumors. Our results demonstrated DKI-MRI may provide the potential biomarkers on the change of microenvironment in the application of 3D cell culture experiment.

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