Abstract #3884

Disrupted Cerebellar Connectivity with the Central Executive Network and the Default-mode Network in unmedicated Bipolar II Disorder

Xiaomei Luo^1,2, Guanmao Chen¹, Yanbin Jia³, Jiaying Gong⁴, Shaojuan Qiu¹, Shuming Zhong³, Lianping Zhao⁵, Feng Chen¹, Shunkai Lai³, Zhangzhang Qi⁠¹, Long Qian⁶, Li Huang¹, and Ying Wang¹

¹Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, ²Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China, ³Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China, ⁴Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁵Department of Radiology, Gansu Provincial Hospital, Gansu, China, ⁶GE Healthcare, MR Research China, Beijing, China

The present study aims to investigate the FC between the cerebellum and cerebrum, particularly the central executive network (CEN) and the default-mode network (DMN) in BD II. Seed-based connectivity analyses were performed in 94 unmedicated BD II depression and 100 healthy controls (HCs). Patients with BD II depression showed disrupted FC between the cerebellum and the CEN (mainly in the left dlPFC and ACC) and DMN (mainly in the left mPFC and temporal lobe), suggesting the significant role of the cerebellum-CEN and -DMN connectivity in the pathogenesis of BD.

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