Abstract #3883

Hemisphere-specificity between global synchronization of spontaneous brain activity and movement function in Hippocampus of Parkinson’s disease patients: a resting-state fMRI study

Yanjun Liu^1,2, Mengyan Li³, Haobo Chen³, Shaode Yu¹, Guihe Hu³, Xiuhang Ruan⁴, Xinhua Wei⁴, and Yaoqin Xie¹

¹Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Deep Bay Innovation Co., Ltd., Shenzhen, China, ³Department of Neurology, Guangzhou First People’s Hospital, Guangzhou, China, ⁴Department of Radiology, Guangzhou First People’s Hospital, Guangzhou, China

This study enrolled age-match of 36 people with PD and 35 normal controls (NC) in resting-state functional MRI. Altered global signal synchronizations in PD were explored, and correlations between global synchronizations and clinical assessments (cognitive and movement functions) were investigated. Alterations of global synchronizations were observed in left postcentral gyrus (PostC), left supramarginal gyrus and right opercular-inferior frontal gyrus in people with PD. The correlation results imply postcentral gyrus and hippocampus as critical brain regions associated with both cognitive performances and movement functions in PD.

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