The rhinencephalic brain regions are specifically vulnerable to AD pathology. This suggests that olfactory assessment may be able to serve as a measure of AD progression. In this research, we investigated the functional connectivity (FC) between the olfactory network (ON) and the hippocampus as a sensitive marker to detect progressive AD pathophysiology. The results show that the ON FC is able to differentiate between early mild cognitive impairment (MCI) and late MCI subjects. As such, ON FC may provide critical insights into relationships between olfactory, memory and, other cognitive deficits in AD.
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