Abstract #4208

In vivo study of cerebral NAD contents and Redox State during mouse brain development.

Radek Skupienski^1,2,3, Kim Do¹, Roger Marti³, and Lijing Xin²

¹Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Prilly, Switzerland, ²Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³HES-SO, University of Applied Sciences of Western Switzerland, HEIA-FR, Institute of Chemical Technology, Fribourg, Switzerland

Nicotinamide adenine dinucleotide (NAD⁺ and NADH) is a key player of cell energy metabolism. ³¹P-MRS has been demonstrated for in vivo measurement of NAD content and redox state in cat and human brain. We previously demonstrated the feasibility of NAD measurement in mouse brain, and actually we established the in vivo profile of cerebral NAD⁺, NADH and NAD⁺/NADH at different ages. This study demonstrated also the feasibility of in vivo measurement of NAD⁺, NADH and redox state from 20 to 250 days old animals and it opens widely the prospect of studying longitudinally the energy metabolism and redox dysfunction in mouse models of brain pathologies.

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