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Abstract #4209

Fluorine-19 Magnetic Resonance Thermometry: Temperature Dependence of Spin-Lattice and Spin-Spin-Relaxation Times of Fluorinated Drugs at 9.4 T

Christian Prinz1, Paula Ramos Delgado1, Thomas Wilhelm Eigentler1, Ludger Starke1, Thoralf Niendorf1,2, and Sonia Waiczies1

1Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany

Fluorine-19 (19F) magnetic resonance is a powerful tool for tracking fluorine labelled markers, cells and drugs. Here, we studied the influence of temperature on the 19F MR characteristics (chemical shift, T1, T2, SNR) of four fluorinated drugs using 19F MR mapping and spectroscopy techniques. We demonstrated the impact of temperature on the T1 relaxation time of PFCE nanoparticles in vivo and postmortem. Our findings open a trajectory toward 19F MR-based thermometry and indicate the need for adapting MR sequence parameters according to temperature induced environmental changes. This will be an essential requirement for monitoring fluorinated compounds by 19F MR techniques in vivo.

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