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Abstract #4231

Towards probing diffusion barriers for water and metabolites in skeletal muscle by MR spectroscopy using oscillating and pulsed diffusion gradients with a large range of diffusion times

Kadir Simsek1, Andre Döring1, and Roland Kreis1

1Departments of Radiology and Biomedical Research, University Bern, Bern, Switzerland

Diffusion-weighted MR spectroscopy has recently been shown to help elucidate the microstructure of brain tissue and the use of oscillating gradients in MRI has provided the option to study local features on a smaller scale. Here, we aim at combining both techniques to investigate human skeletal muscle in vivo on a clinical scanner. Oscillating and pulsed gradient schemes with a large range of diffusion times were applied with otherwise identical acquisition settings. Initial results are shown, but also the challenges faced for muscle where physiologic pulsation and gradient-related artifacts may be prominent.

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