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Abstract #4312

Cardiac metabolic imaging using hyperpolarized [1-13C]lactate as a substrate

Angus Z Lau1,2, Albert P Chen3, and Charles H Cunningham1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 3GE Healthcare, Toronto, ON, Canada

The use of hyperpolarized [1-13C]lactic acid as a substrate for studying cardiac metabolism is attractive due to its high safety profile. 13C metabolite images were acquired following injection of hyperpolarized [1-13C]lactate in the porcine heart. The appearance of 13C-bicarbonate and absence of 13C-pyruvate in these images demonstrates rapid decarboxylation of pyruvate within the cardiac tissue.

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