Abstract #4313

Effect of Opening the Blood-Brain Barrier with Focused Ultrasound on 13C Hyperpolarized Imaging in Rat Brain

Edward P Hackett¹, Bingbing Cheng², Daniel M Spielman³, Kelvin L Billingsley⁴, Rajiv Chopra², and Jae Mo Park^1,2,5

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Radiology, Stanford University, Stanford, CA, United States, ⁴Chemistry and Biochemistry, California State University Fullerton, Fullerton, CA, United States, ⁵Electrical and Computer Engineering, University of Texas Dallas, Richardson, TX, United States

We examined how opening the blood-brain barrier (BBB) with focused ultrasound (FUS) pulses changes the uptake and metabolism of hyperpolarized [1-¹³C]pyruvate and [1-¹³C]glycerate in the brain. We observed larger amounts of metabolic products, lactate and bicarbonate, from hyperpolarized [1-¹³C]pyruvate in the brain region where FUS was applied. Moreover, increased [1-¹³C]glycerate uptake in the brain was detected after the FUS-induced BBB opening.

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