Abstract #4314

Hyperpolarized 13C MRI Cellular Transport Modeling

Zijun Cui^1,2, Xucheng Zhu², Renuka Sriram², Zhen Jane Wang², and Peder EZ Larson²

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Hyperpolarized (HP) ¹³C MRI is very appealing due to its potential in imaging the dynamic metabolic conversion and transport process. In this work, we tried to model the cellular transport process for dynamic HP ¹³C studies. Two highlights in this work are, (1) separating intra- and extracellular HP [1-¹³C] lactate based on dynamic HP ¹³C diffusion weighted imaging (DWI) technique, (2) extending standard k_plmodel to quantify cellular transport, with applications to cancer cell studies and cancer mouse studies.

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