Abstract #0385

MRSI of the prostate revisited: The potential role of GOIA-sLASER in multiparametric MRI of central gland prostate cancer

Neda Gholizadeh¹, Peter B Greer^2,3, John Simpson^2,3, Jonathan Goodwin^2,3, Peter Lau^4,5, Arend Heerschap⁶, and Saadallah Ramadan^1,5

¹Health Science, The University of Newcastle, Newcastle, Australia, ²Radiation Oncology, Calvary Mater Newcastle, Newcastle, Australia, ³Physics and mathematics, The University of Newcastle, Newcastle, Australia, ⁴Radiology, Calvary Mater Newcastle, Newcastle, Australia, ⁵Imaging Centre, Hunter Medical Research Institute (HMRI), Newcastle, Australia, ⁶Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Nijmegen, Netherlands

Due to histological heterogeneity of the central gland, accurate detection of central gland prostate cancer remains a challenge. A reliable and non-invasive imaging technique could increase the sensitivity and specificity for identification of central gland lesions missed by PI-RADS V2 or biopsies. This study evaluates the diagnostic performance of individual and combined parameters of an mp-MRI exam, employed for PI-RADS evaluations (T2WI, DWI, DCE) and advanced GOIA-sLASER MRSI using an external phased-array coil for central gland prostate cancer detection, localization and grading. The results demonstrate that MRSI using GOIA-sLASER considerably improves central gland prostate cancer detection and localization.

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