Abstract #1108

Effective oxygen diffusivity mapping with multiparametric quantitative BOLD and pCASL: Comparison between healthy young and elderly subjects

Jan Kufer¹, Jens Goettler^1,2,3, Samira Epp¹, Mikkel Bo Hansen⁴, Claus Zimmer¹, Kim Mouridsen⁴, Fahmeed Hyder², Christine Preibisch^1,5, and Stephan Kaczmarz^1,2

¹School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, ²MRRC, Yale University, New Haven, CT, United States, ³School of Medicine, Department of Radiology, Technical University of Munich, Munich, Germany, ⁴Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁵School of Medicine, Clinic of Neurology, Technical University of Munich, Munich, Germany

The effective oxygen diffusivity (EOD) of the capillary bed has gained increasing interest as a promising biomarker providing additional information on microvascular integrity. To overcome limitations in the applicability of existing and relatively complex EOD mapping techniques, we proposed a novel more easily applicable MR-based approach. We measured EOD in 16 young and 30 elderly healthy subjects. Our measurements of EOD by MRI in young subjects yielded comparably good results in comparison with PET-data as a reference. Furthermore, we found EOD reductions in elderly healthy subjects with concomitant capillary transit-time heterogeneity (CTH) increases, indicating disturbed capillary oxygen extraction ability.

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