Calibrated fMRI can map the rate of cerebral oxygen consumption of the human brain, offering an important indicator of energy dysfunction in neurodegenerative and neuroinflammatory diseases. Previous studies investigated oxygen metabolism at rest or in response to tasks within BOLD signal defined region of interests (ROIs). Here, we investigate on a voxel-by-voxel basis the oxygen metabolic activity in patients with multiple sclerosis during the execution of a task. We show the feasibility of mapping task-induced CMRO2 changes, demonstrating reduced oxygen consumption in the basal ganglia in MS patients that was not otherwise evident from BOLD or CBF signals.
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