Imaging of skeletal muscle contraction using Oscillating Gradient Spin Echo (OGSE)

The apparent diffusion coefficient measured using DTI in skeletal muscles depends on the time allowed for diffusing water molecules to probe the local environment and on the size of muscle cells. Here we explore the use of Oscillating Gradient Spin Echo diffusion to obtain information on skeletal muscle microstructure over smaller distances than conventionally probed using PGSE. Our results show the ability to image skeletal muscle during active contraction (foot dorsiflexion and plantarflexion) using OGSE, and diffusion values are dependent on the oscillation frequency and on the contraction status of the muscle