Abstract #1481

Longitudinal assessment of brain iron deposition in Alzheimer’s disease

Christian Langkammer¹, Anna Damulina¹, Lukas Pirpamer¹, Martin Soellradl¹, Edith Hofer^1,2, Christian Tinauer¹, Maximilian Sackl¹, Christian Enzinger^1,3, Stefan Ropele¹, and Reinhold Schmidt¹

¹Department of Neurology, Medical University of Graz, Graz, Austria, ²Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria, ³Department of Radiology, Medical University of Graz, Graz, Austria

Using R2* relaxation rate mapping we found higher iron concentrations in the deep grey matter and neocortical regions in 101 patients with Alzheimer’s disease compared to 101 age-matched community-dwelling individuals. AD patients had significantly higher R2* in the temporal and occipital lobes and caudate nuclei. Independently of brain volume loss, changes in cortical iron levels over time were associated with cognitive decline in participants with Alzheimer's disease.

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