Abstract #1482

Quantitative T1 mapping of the substantia nigra using phase-sensitive inversion recovery: a healthy volunteer study at 3.0 T

Yasuhiro Fujiwara¹, Tetsuyoshi Hirai², Tomohiro Ueda², Hiroyuki Kumazoe², and Shigeki Ito³

¹Department of Medical Image Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ²Department of Radiology, National Hospital Organization Omuta National Hospital, Omuta, Japan, ³Department of Medical Radiation Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

We estimated the T1 values of the SN in healthy subjects and clarified its correlation with the SN characteristics obtained in neuromelanin (NM) images to identify an imaging biomarker for early diagnosis of PD. In healthy adults, the area and T1 value of the SN, measured quantitatively from PSIR images, has different characteristics from those obtained from NM images, and may help assess SN degeneration.

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